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Naoki Komatsu Selected Research

Neoplasms (Cancer)

12/2022Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery.
9/2021Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.
9/2021Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
7/2020Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near-Infrared Fluorescence In Vivo Tumor Imaging.
11/2019Preferential Tumor Accumulation of Polyglycerol Functionalized Nanodiamond Conjugated with Cyanine Dye Leading to Near-Infrared Fluorescence In Vivo Tumor Imaging.
10/2019Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer.
5/2019Size-tunable MRI-visible nitroxide-based magnetic mixed micelles: preparation, stability, and theranostic application.
1/2019Single-Cell Live Imaging.
10/2018Dendritic cell-mediated delivery of doxorubicin-polyglycerol-nanodiamond composites elicits enhanced anti-cancer immune response in glioblastoma.
1/2018Correction to "Direct Fabrication of the Graphene-Based Composite for Cancer Phototherapy through Graphite Exfoliation with a Photosensitizer".
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Naoki Komatsu Research Topics

Disease

23Neoplasms (Cancer)
12/2022 - 01/2007
6Glioblastoma (Glioblastoma Multiforme)
10/2020 - 12/2017
5Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
11/2009 - 11/2004
5Leukemia
09/2009 - 10/2006
3Lung Neoplasms (Lung Cancer)
09/2021 - 01/2006
3Inflammation (Inflammations)
11/2013 - 12/2008
3Immediate Hypersensitivity
11/2009 - 12/2008
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2009 - 06/2007
2Triple Negative Breast Neoplasms
09/2021 - 10/2019
2Brain Neoplasms (Brain Tumor)
10/2018 - 01/2007
2Glaucoma
01/2018 - 08/2003
2Multiple Myeloma
03/2012 - 10/2006
2Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
07/2009 - 02/2008
2Hypersensitivity (Allergy)
02/2009 - 11/2004
2Blast Crisis (Blast Phase)
09/2007 - 10/2006
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2007 - 01/2006
1Carcinoma (Carcinomatosis)
01/2021
1Open-Angle Glaucoma (Glaucoma, Open Angle)
01/2018
1Neovascular Glaucoma
01/2018
1Ovarian Neoplasms (Ovarian Cancer)
12/2016
1Cytomegalovirus Infections (Inclusion Disease)
11/2013
1Shock
11/2011
1Infections
06/2011
1Hyperthermia
03/2011
1AIDS-Related Complex (ARC)
06/2010
1Acute Monocytic Leukemia (Acute Monoblastic Leukemia)
06/2008
1Acute Biphenotypic Leukemia (Leukemia, Mixed Cell)
06/2008
1Keratitis
01/2008

Drug/Important Bio-Agent (IBA)

10NanodiamondsIBA
09/2021 - 11/2011
8polyglycerolIBA
10/2020 - 07/2014
7Pharmaceutical PreparationsIBA
12/2022 - 07/2014
7Doxorubicin (Adriamycin)FDA LinkGeneric
09/2021 - 10/2018
5DNA (Deoxyribonucleic Acid)IBA
11/2013 - 08/2003
4AllergensIBA
11/2009 - 08/2008
3Proteins (Proteins, Gene)FDA Link
01/2021 - 10/2006
3Photosensitizing Agents (Photosensitizers)IBA
01/2018 - 10/2015
3Histone Deacetylase InhibitorsIBA
09/2009 - 01/2006
3Phosphotransferases (Kinase)IBA
06/2008 - 06/2007
2CytokinesIBA
09/2021 - 01/2018
2Coloring Agents (Dyes)IBA
07/2020 - 11/2019
2GraphiteIBA
01/2018 - 10/2015
21-phenyl-3,3-dimethyltriazene (PDT)IBA
12/2016 - 03/2011
2ragweed pollenIBA
11/2009 - 12/2008
2AZD 6244IBA
09/2009 - 06/2008
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
09/2009 - 06/2008
2Chemokine ReceptorsIBA
02/2009 - 12/2008
2Sunitinib (Sutent)FDA Link
06/2008 - 10/2006
2Aurora KinasesIBA
09/2007 - 06/2007
2ThymidineIBA
09/2007 - 06/2007
2VorinostatFDA Link
08/2007 - 01/2006
2Histones (Histone)IBA
03/2007 - 01/2006
1HMGB1 Protein (HMG1)IBA
09/2021
1Interleukin-6 (Interleukin 6)IBA
09/2021
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
09/2021
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
09/2021
1Protein CoronaIBA
01/2021
1diazonaphthalenedisulfonic acid (NDS)IBA
01/2021
1Cytostatic AgentsIBA
10/2019
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
10/2019
1MicellesIBA
05/2019
1Paclitaxel (Taxol)FDA LinkGeneric
05/2019
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
05/2019
1Interleukin-8 (Interleukin 8)IBA
01/2018
1phytochlorinIBA
12/2016
1Therapeutic UsesIBA
12/2016
1Peptides (Polypeptides)IBA
07/2014
1arginyl-glycyl-aspartic acidIBA
07/2014
1Drug CarriersIBA
07/2014
1Bone Morphogenetic Protein 6IBA
03/2012
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
03/2012
1Transforming Growth Factors (Transforming Growth Factor)IBA
03/2012
1Antiviral Agents (Antivirals)IBA
06/2011
1Biological ProductsIBA
03/2011
1Singlet OxygenIBA
03/2011
1Heme (Haem)IBA
03/2011
1protoporphyrin IXIBA
03/2011
1AcidsIBA
03/2011
1PolymersIBA
06/2010
1Detergents (Detergent)IBA
06/2010
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
11/2009
1CCR2 ReceptorsIBA
11/2009
1RS 504393IBA
11/2009
1Mitogen-Activated Protein KinasesIBA
09/2009
1MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA
09/2009
1Matrix Metalloproteinases (MMPs)IBA
07/2009
1Immunoglobulin E (IgE)IBA
02/2009
1Chemokine CCL11IBA
02/2009
1NF-kappa B (NF-kB)IBA
02/2008
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
12/2007
1Messenger RNA (mRNA)IBA
12/2007
1TubulinIBA
09/2007

Therapy/Procedure

6Therapeutics
10/2020 - 01/2007
4Drug Therapy (Chemotherapy)
10/2019 - 01/2006
2Immunotherapy
10/2019 - 03/2011
2Phototherapy (Light Therapy)
01/2018 - 10/2015
2Photochemotherapy (Photodynamic Therapy)
12/2016 - 03/2011
1Ligation
09/2021
1Combined Modality Therapy
10/2018
1Laser Therapy (Surgery, Laser)
06/2010
1Injections
08/2008